O_O means “ Confused“. Answer to What does O_O mean is “ Confused”. This Page tells the meaning and definition of Slang word O_O. What does O_O Mean? O_O mean “ Confused”. This is the exact meaning of the English Slang word O_O. O_O Meaning/Definition The Exact meaning of O_O is “ Confused”. Or, You can say that, The Definition of O_O is “ Confused”.